Cannabis is regularly found bystudiesto be the least risky amateur drug , and has not yet caused anoverdose deaththat we know of . Now that that ’s out of the way of life , let ’s look at a time that researcher deliberately give subjects a eminent superman of tetrahydrocannabinol ( THC ) to study its effects .

" Cannabis has been historically classified as a hallucinogen . However , subjective cannabis effects do not typically admit hallucinogen - similar effects , " the squad explicate in their work . They also note that hallucinogenic - like effect generally befall in volunteers who were give make pure tetrahydrocannabinol rather than whole - plant cannabis , and case reports involving hallucinations lean to occur in patients with a story of psychosis .

In this dual - blind , placebo - moderate study , the squad see at the effects of big doses of evaporate THC on military volunteer , and compared it to the outcome of ingest ganja , psilocybin , and other hallucinogens .

In the cannabis portion of the study , volunteers smoked cannabis which contained either 0 , 10 , or 25   miligrams of THC , consumed within 10 minutes . In one volunteer , the focus of the paper due to the consequence it had on him , the effects of this percentage of the experiment were minimal and let in cardiovascular effects as well as a morsel of deadening on cognitive examination . However , when he claim part in the fourth form of the experiment – inhaling vaporise cannabis that contained 25   milligrams of THC , the result were far stronger , and got more and more bad during the first 20 arcminute after inhalation .

" He had trouble reply to staff inquiries , was unable to complete ego - report questionnaires , had trouble keeping his heading up , and appeared to periodically shine deceased or mislay awareness despite boost by enquiry staff to detain awake and cover , " the team write , adding ( probably unnecessarily ) that he " was ineffective to maintain a balanced , steady pace when he walked . "

The voluntary , named H.C. in the paper , had trouble staying conscious , though his critical signs remained within normal ranges . For the next few hours , he rest in a state of matter which was n’t idealistic for experimenter , given that he was unable to do cognitive tests , and when he could sing it was for the most part to report that he felt nauseated and was experiencing pain and tingling in his limbs and neck . When he was more able of communication , a full three hours after the initial VD , HC reported that he had experienced a number of strange hallucinogenic effects .

" He described optical distortions in the figure of the environment and level sinking off and the show of pattern moving on the rug and death chair in the way , " the squad wrote . " Additionally , he reported an ' out - of - dead body ' experience characterized by the feeling of being removed from his trunk , existing above it in quad , and feeling that his environs were sinking away from him , which was also accompanied by a impression of paralysis . "

After another few hours and some lunch , these feeling of nausea and disassociation went away , and he was capable to complete experiment questionnaires and cognitive tests . Though he reported large change on the Intensity , Somaesthesia , Perception , and Volition subscales of theHallucinogen Rating Scale(HRS ) , his experience differed from those on other hallucinogenic drugs on cognition and affect .

" Given that change in affect and cognition are core characteristic of experience with classic hallucinogenic drug , it is unmanageable to assign the report vitrine as an experience similar to that of a true classic psychedelic drug , " the team wrote , note that it was " curious " that he had not experience the same effects when smoking whole marihuana with the same dosage of THC . The team think this could partly be put down to other element in cannabis , smoke or ingested at the same prison term as THC .

" This eminence is worth take note as it channelise to exogenous CB1 receptor agonism as a likely mechanism for induce hallucination , " the team write , " and also because it has been postulated that phytocannabinoids such as cannabidiol ( CBD ) or terpenoids that are present in the cannabis industrial plant may mitigate some of the deleterious effect of THC . "

The study is publish inCannabis and Cannabinoid Research .