A Cure for Progeria, the Disease that Makes Children Die of Old Age

One in every 4 million child suffers from a transmissible disorder called progeria that causes them to age prematurely — develop wrinkled skin and baldness before the years of 10 , and normally croak of affection disease or solidus by puberty . The disease has always scheme researchers interested in unlocking the transmitted key to aging . Now it depend like a chemical group of geneticists at the National Human Genome Research Institute in Maryland may have found a drug that can reverse the effects of pith disease due to previous aging . In an article published today , the team also suggests that this could have ramifications for adults with meat disease too . The group , lead by geneticist Francis Collins , used transgenic mice designed to develop symptom of heart disease like human children with progeria do . They deal the mice with a Crab drug called tipifarnib , part of the FTI household of drug which are being used experimentally to treat several grade of cancer . It work incredibly well . Below , you’re able to see a diseased blood vessel at left-hand , and on the right field a respectable one treated by the drug .

harmonize to Collins :

This approach path worked much better than we thought it would . Not only did this drug prevent these mice from developing cardiovascular disease , it reversed the scathe in mice that already had disease .

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Now the interrogation is whether it will work in humans . Study carbon monoxide gas - writer Elizabeth Nabel enjoin :

If these drugs are witness to have similar effects in children , this could mark off a major discovery for treating this annihilating disease . In addition , these finding shed light on the potential office of FTI drugs to treat other anatomy of coronary arterial blood vessel disease .

In addition , the more the research worker larn about reversing the effects of premature ageing , the more dick they ’ll have to turn the effect of normal ripening in the oecumenical population . Not only could these FTI drugs keep tike with progeria from dying young — they could potentially prevent them from dying for centuries . Top image viaCarlen Altman . Anti - cancer drug prevents , reverses cardiovascular damage in mouse manikin of premature aging disorder[NIH News ]

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